Persistent deficits in bone quality in treated acromegaly: evidence from assessments of microstructure

Abstract Purpose Fractures are increased in patients with acromegaly, both before and after successful acromegaly treatment. Abnormalities of bone microstructure, which may underlie this fragility, present active but to what extent these improve treatment or persist despite biochemical remission remains unclear. To examine questions, we studied the effects on quality. Methods 65 women men were studied. Sub-groups underwent assessments aBMD by DXA, Trabecular score (TBS) volumetric BMD, microarchitecture, stiffness failure load distal radius tibia HRpQCT a longitudinal study cross-sectional compared gender, age BMI matched healthy controls. Results In study, significant increases total, cortical trabecular densities at occurred surgery had larger bones, lower density disrupted microarchitecture TBS did not change correlated some microstructural parameters. Conclusions We show, for first time, that BMD peripheral skeleton remain abnormal These abnormalities, known be associated fractures other populations, play role pathogenesis persistent fragility treated acromegaly.